The American Cancer Society (ACS) and the American Cancer Society Cancer Action Network (ACS CAN) appreciate the opportunity to comment on the scientific report of the 2025 Dietary Guidelines Advisory Committee. Overall, we strongly support the conclusions and recommendations in the DGAC Report. The following comments provide additional information on the role of diet in cancer and specific recommendations for those tasked with finalizing the 2025-2030 Dietary Guidelines for Americans (DGA).